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Treatment of AcneII Classification of Acne Grade of. 













































     


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Benzac ac para cravos. Treatment of AcneII Classification of Acne Grade of



   

Pustular - an oral antibiotic would be best: Comedonal acne - topical treatment appropriate:. AMP, c. GMP and RNA polymerase l Action in acne: 1 decreased cohesion between epidermal cells 2 increased epidermal cell turnover.

Less irritating. May increase tumerogenic potential of UV radiation in animals. Thus, patients are advised to minimize or avoid sun exposure and use protective sunscreen 3. Allergic contact dermatitis: rare. Adapalene Differin l A derivative of naphathoic acid that resembles retinoic acid in structure and effects l Applied 0. Tazarotene Tazorac l Acetylenic retinoid l 0. Isotretinoin Accutane l A synthetic retinoid currently restricted to the treatment of severe cystic acne that is recalcitrant to standard therapies; l Well absorbed to circulation, extensively bound to plasma albumin, l elimination half-life of 21 para que es la crema benzac parent drug21 hrs metabolite l MOA: inhibits sebaceous gland size and function ….

MOA- isotretenoin: l Isotretinoin prevents the formation of new comedos and resultant inflammatory lesions by: 1. Isotretinoin Accutane Dose: l 0. Patient is at high risk for abnormal healing and development of excessive granulation following procedures e. Isotretinoin Accutane Adverse Effects Common adverse effects resemble hypervitaminosis A : l Dryness and itching of skin and mucous membranes l Less common: Headache, corneal opacities, pseudotumpr cerebri inflammatory bowel disease, anorexia, alopecia, muscle and joint pains l These effects are all reversible on discontinuation of therapy.

Teratogenecity l the skull, ears, and eyes and include facial dysmorphia and cleft palate. Isotretinoin Accutane Teratogenecity 1. Women of childbearing age must use an effective form of contraception for at least 1 month before; throughout isotretinoin therapy, and for one or more menstrual cycles following discontinuance of therapy 2.

A serum pregnancy test must be obtained within 2 weeks before starting therapy 3. Therapy should be initiated only on the second or third day after the next normal menstrual period. Isotretinoin Accutane Monitoring parameters: 1. Pregnancy tests 3.

Creatine Phosphokinase 6. Blood Glucose. Azelaic Acid Azelex l l 1. Then twice daily thereafter Mild irritation with redness and dryness of the skin during the first week of treatment Clinical improvement 6 -8 weeks of continuous therapy. Topical Antibiotics l Commonly prescribed: erythromycin and clindamycin alone or in combination with benzoyl peroxide l MOA: 1 bactericidal activity against P acnes.

Systemic Antibiotics l Tetracycline and congeners minocycline and doxycycline l Erythromycin, azithromycin l Trimethoprim alone or in combination with sulfamethoxazole l MOA: 1 P acnes; 2 Anti-inflammatory l Minocycline is more effective than tetracycline and bacteria has less resistance to this agent.

Hormonal Therapy l MOA: estrogens are responsible for maintenance of the normal structure and function of the skin and blood vessels l Acne may be exacerbated by agents containing androgen-like progestins e. Progestin Progestational Activity relative to 1 mg of norethindrone Androgenic Activity relative to 1 mg of norethindrone norethindrone 1 mg 1. Tri Cyclen may take 3 -4 months to become apparent; l Main limitation of anti-androgen therapy for acne is that it cannot be used with male patients.

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