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Diagnosis and Treatment of Acne | AAFP.Iodine is not available outside of the United States |
Benzaclin and doxycycline -
Taking the stress out of acne management - PMC.
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For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Results First Posted : August 31, Last Update Posted : May 25, Study Description.
To compare the efficacy and safety of Benzoyl peroxide used in combination with clindamycin vs. Benzoyl peroxide used in combination with clindamycin and doxycycline in the treatment of moderate acne. Detailed Description:. Benzoyl peroxide used in combination with clindamycin and doxycycline once daily in the treatment of moderate acne. Drug Information available for: Benzoyl peroxide Doxycycline Doxycycline monohydrate Clindamycin Clindamycin hydrochloride Doxycycline hyclate Clindamycin phosphate Clindamycin palmitate hydrochloride Clindamycin palmitate Doxycycline calcium.
FDA Resources. Arms and Interventions. Benzoyl peroxide BPO wash with clindamycin foam and doxycycline capsules. Benzoyl peroxide wash - Clindamycin foam - Doxycycline capsules. Outcome Measures. Percent change in Non-inflammatory acne lesions whiteheads and blackheads chest and back from baseline to week IGA scale: 0 - Clear 0. Percent change in non-inflammatory lesions chest and back from baseline to Week Percent change in total lesions chest and back from baseline to Week Eligibility Criteria.
Inclusion Criteria: Male or female subjects with acne vulgaris. Exclusion Criteria: Known hypersensitivity to any of the components of the study drugs or used of prohibited medications or any medical condition that contraindicate the subject's participation in the clinical study. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Drug: Benzoyl peroxide with clindamycin Drug: Benzoyl peroxide with clindamycin and doxycycline. Phase 4. Study Type :. Interventional Clinical Trial. Actual Enrollment :.
Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Drug: Benzoyl peroxide with clindamycin and doxycycline Benzoyl peroxide wash - Clindamycin foam - Doxycycline capsules Other Name: Acne.
February 5, Key Record Dates.
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The new PMC design is here! Learn more about navigating our updated article layout. The PMC legacy view will also be available for a limited time. Federal government websites often end in. The site is secure. The first-year family medicine resident you supervise sees a year-old woman in your clinic who requests treatment for facial acne. The patient is generally healthy, has no known allergies, and is taking Yasmin for contraception.
She was hoping Yasmin would improve her skin, but after 6 months of use she is still getting frequent pimples. She washes her face with regular soap several times a day and uses a moisturizer and makeup daily.
She asks about Proactiv, which she saw advertised on television. She has no acne lesions on her back or chest. The resident reports that the patient has mostly papules and pustules on her face along with some comedones. There is no scarring. He is uncertain how to describe the severity of the acne and how to treat it.
The presence of facial papules and pustules, few comedones, and no nodules or scarring suggests mild to moderate acne severity. For this patient, limiting face washing to once or twice daily with mild soap or soapless cleanser is an important first step.
Frequent washing causes ongoing trauma to the pores, which worsens the condition. It is also important to discuss use of noncomedogenic makeup products. Options for initial therapy can include roles for topical products, such as benzoyl peroxide BPtopical retinoids, topical or oral antibiotics, and combinations of the above.
Benzoyl peroxide has multiple mechanisms of action including being anti-inflammatoryis not associated with any bacterial resistance, and is inexpensive. Topical retinoids are considered useful for comedonal lesions and long-term acne control; however, they are more expensive. Topical antibiotics are a potential step-up therapy in papulopustular inflammatory acne. To reduce bacterial resistance, topical antibiotics should be used in combination with BP. Response is often seen within 3 months, after which time the topical antibiotic can be discontinued and a topical retinoid or BP can be used for maintenance therapy.
The chart provided information on benefits, harms, use, and comparative cost. Table 1 712 — 19 provides an overview of acne pharmacotherapy; the full version of the RxFiles chart is available from CFPlus. David, a year-old male patient, has been seeing his family physician for the past 4 years.
Initially, David had mild inflammatory acne on his face and was treated successfully with clindamycin-BP gel. Two years ago his acne worsened, with comedones, papules, and pustules on his face and upper back.
He was prescribed doxycycline mg daily for 4 months. A dramatic response was seen and David resumed topical therapy. One year later he required another course of doxycycline; the acne improved somewhat, but within a few months he developed more papular and nodulocystic lesions with scarring on his face and upper back.
He therefore returned to request a different antibiotic. Is minocycline a better oral antibiotic for acne? Studies have not shown differences in efficacy among oral antibiotics. She reviewed important precautions and side effects with David, along with methods to manage them.
She recommended 0. David returned after 1 month, happy with the initial response to therapy. Following initiation of isotretinoin, it is important to monitor side effects and benzac gel torrinomedica dosing adjustments as necessary.
David is pleased with the effect of isotretinoin on his acne, but is experiencing some muscle benzac acquista online joint pain that is worse after exercise. He is on the high school football team and is concerned that he will not be able to play if the arthralgia worsens.
His physician therefore decides to continue the lower dose 0. David has no further problems and returns for monthly follow-up as recommended.
After 4 months of taking isotretinoin, his skin is totally clear with no new acne lesions in the past 6 weeks. He has had no further side effects but continues to have mild leg arthralgia, and is hoping to discontinue therapy. RxFiles is an academic detailing program providing objective comparative drug information to physicians, pharmacists, and allied health professionals.
The program began in as a service to family physicians in Saskatoon, Sask. Inthe program was expanded to provide service to physicians throughout Saskatchewan. Efforts to keep the drug selection tools up-to-date resulted in the publication of the RxFiles Drug Comparison Charts, beginning in The book has become a practical tool for evidence-based and clinically relevant drug use information throughout Canada.
RxFiles charts begin with input from family physicians, other specialists, and pharmacists on current questions, information needs, and practice gaps. An extensive review of the literature provides the foundation for incorporating evidence and information relevant to prescribing decisions.
The review looks to systematic reviews, original landmark trials, clinical practice guidelines, and many other information sources. An emphasis is placed on noting the most important clinical outcomes, risk-benefit assessment, patient safety, and cost considerations.
RxFiles continues to serve health providers and educators through newsletter reviews, question-and-answer summaries, trial summaries, and up-to-date drug comparison charts. The clinical relevance of these materials comes from their initial focus as academic detailing tools for front-line practitioners wanting to provide the best possible drug therapy for their patients.
Go to the full text of the article on-line, then click on CFPlus in the menu at the top right of the page. RxFiles and contributing authors do not have any commercial competing interests. Can Fam Physician. Author information Copyright and License information Disclaimer. Case 1 The first-year family medicine resident you supervise sees a year-old woman in your clinic who requests treatment for facial acne.
Alternate initiation regimens are also possible. Patients should be warned that BP can bleach clothing, bedding, and hair. Combination of BP and topical clindamycin is superior to use of either ingredient alone.
After the condition improves, stepping down to monotherapy with BP, a retinoid, or both can be considered. Open in a separate window. Case 2 David, a year-old male patient, has been seeing his family physician for the past 4 years. While taking isotretinoin, other topicals are generally avoided, as they worsen the dryness that commonly occurs during therapy. Noncomedogenic and drying effects of the isotretinoin persist several months after discontinuation.
If a retinoid or BP is used for maintenance therapy after isotretinoin, delaying initiation for at least 4 months is often necessary while dry or sensitive skin and membranes persist.
RxFILES RxFiles is an academic detailing program providing objective comparative drug information to physicians, pharmacists, and allied health professionals. Competing interests RxFiles and contributing authors do not have any commercial competing interests. References 1. James WD. Clinical practice. N Engl J Med. Guidelines for treating acne. Clin Derm. Russell JJ. Topical therapy for acne. Am Fam Physician. Layton AM.
A review on the treatment of acne vulgaris. Int J Clin Pract. Health care guideline: acne management. Available from: www. Practical considerations in acne treatment and the clinical impact of topical combination therapy. Pediatr Dermatol. Guidelines of care for acne vulgaris management. J Am Acad Dermatol. Bershad SV. In the clinic. Ann Intern Med. Comparing 2. Int J Dermatol. Am J Clin Dermatol. Expert committee recommendations for acne management.
European recommendations on the use of oral antibiotics for acne. Eur J Dermatol.
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